Featured News

We are pleased to share that our new paper, “What we thought we knew about TNF—And what we now must re-learn,” has been published in Stem Cell Reports.

 

In this article, we revisit the role of tumor necrosis factor (TNF) in hematopoiesis and discuss emerging evidence showing that its effects on hematopoietic stem cells (HSCs) are not simply suppressive, but depend on cell type, context, and timing. Rather than acting as a uniformly harmful signal, TNF may deplete progenitor populations while transiently reprogramming HSCs without necessarily compromising their long-term regenerative potential.

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2026-02-26